Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.75 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28999860 | 0.86 | SMN1; SMN2 (0.71) | HPGDSMN1; SMN2L3MBTL1NPC1RAB9A | |
| SCHEMBL179082 | 0.81 | HPGD (0.73) | HPGDSMN1; SMN2L3MBTL1NPC1RAB9A | |
| SCHEMBL108701 | 0.80 | KMT2A (0.73) | HPGDSMN1; SMN2L3MBTL1NPC1RAB9A | |
| SCHEMBL17205667 | 0.80 | TRPV1 (0.67) | HPGDSMN1; SMN2L3MBTL1NPC1RAB9A | |
| SCHEMBL17205764 | 0.79 | TRPV1 (0.66) | HPGDSMN1; SMN2L3MBTL1NPC1RAB9A | |
| SCHEMBL28999828 | 0.79 | HPGD (0.61) | HPGDSMN1; SMN2L3MBTL1NPC1RAB9A | |
| SCHEMBL17205973 | 0.79 | USP2 (0.84) | HPGDSMN1; SMN2ALDH1A1TRPV1POLB | |
| SCHEMBL17690748 | 0.78 | HPGD (0.67) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL17205675 | 0.77 | TRPV1 (0.84) | HPGDALDH1A1TRPV1KMT2AMEN1 | |
| SCHEMBL12980467 | 0.77 | TRPV1 (0.65) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | disclosed |