Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | GBA1 | P04062 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653325 | 0.92 | PI4KB (0.46) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL653899 | 0.86 | KCNH2 (0.49) | PI4KBKCNH2GBA1LMNAALOX15 | |
| SCHEMBL1693928 | 0.77 | PI4KB (0.65) | PI4KBKCNH2LMNACYP3A4ALDH1A1 | |
| SCHEMBL794433 | 0.74 | PI4KB (0.57) | PI4KBKCNH2CYP3A4 | |
| SCHEMBL655253 | 0.73 | MEN1 (0.51) | PI4KBKCNH2LMNACYP3A4ALDH1A1 | |
| SCHEMBL653326 | 0.72 | PI4KB (0.56) | PI4KBKCNH2LMNAALOX15CYP3A4 | |
| SCHEMBL652412 | 0.70 | PI4KB (0.65) | PI4KBKCNH2LMNACYP3A4ALDH1A1 | |
| SCHEMBL654037 | 0.69 | GBA1 (0.42) | PI4KBKCNH2GBA1HPGD | |
| SCHEMBL655068 | 0.68 | PI4KB (0.50) | PI4KBKCNH2LMNACYP3A4ALDH1A1 | |
| SCHEMBL655537 | 0.67 | PI4KB (0.68) | PI4KBKCNH2LMNACYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |