Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653262 | 0.92 | MEN1 (0.50) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL655356 | 0.85 | MEN1 (0.39) | MEN1KMT2API4KBKCNH2 | |
| SCHEMBL652418 | 0.78 | PI4KB (0.47) | MEN1KMT2ATSHRSLC27A1ALDH1A1 | |
| SCHEMBL652417 | 0.77 | DRD4 (0.43) | LMNASMN1; SMN2TSHRSLC27A1ALDH1A1 | |
| SCHEMBL653832 | 0.76 | GFER (0.53) | MEN1KMT2AALDH1A1TDP1PI4KB | |
| SCHEMBL16649604 | 0.74 | PI4KB (0.39) | LMNAALDH1A1KDM4EPI4KBGAA | |
| SCHEMBL656147 | 0.73 | LTA4H (0.42) | PI4KBKCNH2 | |
| SCHEMBL655387 | 0.73 | PI4KB (0.53) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4506012 | 0.73 | MEN1 (0.49) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL654037 | 0.72 | GBA1 (0.42) | KMT2ATSHRPI4KBGAAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |