Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSK | P41240 | 2/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.63 |
| ▸ | BRAF | P15056 | 6/20 | 0.62 |
| ▸ | EGFR | P00533 | 4/20 | 0.62 |
| ▸ | ABL1 | P00519 | 11/20 | 0.61 |
| ▸ | BCR | P11274 | 7/20 | 0.61 |
| ▸ | LYN | P07948 | 3/20 | 0.61 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | ARAF | P10398 | 1/20 | 0.61 |
| ▸ | NQO2 | P16083 | 1/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.61 |
| ▸ | ABL2 | P42684 | 1/20 | 0.61 |
| ▸ | FRK | P42685 | 1/20 | 0.61 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2289051 | 0.88 | BRAF (0.77) | BRAFEGFRABL1BCRDDR1 | |
| SCHEMBL17208649 | 0.87 | MAPK14 (0.67) | CSKMAPK14BRAFEGFRABL1 | |
| SCHEMBL15381985 | 0.81 | ABL1 (0.64) | CSKMAPK14BRAFABL1BCR | |
| SCHEMBL17313603 | 0.79 | ABL1 (0.57) | CSKMAPK14BRAFEGFRABL1 | |
| SCHEMBL15860135 | 0.79 | ABL1 (0.57) | CSKMAPK14BRAFEGFRABL1 | |
| SCHEMBL15860133 | 0.79 | ABL1 (0.57) | CSKMAPK14BRAFEGFRABL1 | |
| SCHEMBL15859941 | 0.79 | CSK (0.56) | CSKMAPK14BRAFEGFRABL1 | |
| SCHEMBL17313610 | 0.79 | CSK (0.56) | CSKMAPK14BRAFEGFRABL1 | |
| SCHEMBL17313594 | 0.78 | CSK (0.59) | CSKMAPK14BRAFEGFRABL1 | |
| SCHEMBL17324210 | 0.78 | CSK (0.59) | CSKMAPK14BRAFEGFRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |