Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.60 |
| ▸ | BRAF | P15056 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.56 |
| ▸ | CSK | P41240 | 3/20 | 0.56 |
| ▸ | UBE2N | P61088 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208648 | 0.91 | EGFR (0.59) | EGFRBRAFMAPTKMT2AMAP3K20 | |
| SCHEMBL17208621 | 0.86 | DDR1 (0.68) | EGFRBRAFMAPTKMT2AMAP3K20 | |
| SCHEMBL17208714 | 0.85 | BRAF (0.76) | EGFRBRAFKMT2AATM | |
| SCHEMBL12518524 | 0.80 | BRAF (0.74) | EGFRBRAFMAP3K20MAP3K7MAP4K2 | |
| SCHEMBL13708190 | 0.79 | MAPT (0.53) | EGFRBRAFMAPTRAD52KMT2A | |
| SCHEMBL2285546 | 0.79 | DDR1 (0.71) | EGFRBRAFKMT2AMAP3K20MAP3K7 | |
| SCHEMBL17208647 | 0.78 | BRAF (0.71) | EGFRBRAFMAP3K20MAP3K7MAP4K2 | |
| SCHEMBL2283236 | 0.77 | BRAF (0.64) | EGFRBRAFMAP3K20MAP3K7MAP4K2 | |
| SCHEMBL2283239 | 0.77 | DDR1 (0.74) | EGFRBRAFMAP3K20MAP3K7MAP4K2 | |
| SCHEMBL17208640 | 0.76 | ABL1 (0.56) | EGFRBRAFMAPTRAD52KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |