Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | BRAF | P15056 | 4/20 | 0.59 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.58 |
| ▸ | MAP3K20 | Q9NYL2 | 5/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.57 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.57 |
| ▸ | CSK | P41240 | 3/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.55 |
| ▸ | ABL2 | P42684 | 1/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208621 | 0.93 | DDR1 (0.68) | EGFRBRAFDDR1MAP3K20MAP3K7 | |
| SCHEMBL17208617 | 0.91 | EGFR (0.60) | EGFRBRAFMAP3K20MAP3K7MAP4K2 | |
| SCHEMBL17208647 | 0.86 | BRAF (0.71) | EGFRBRAFDDR1MAP3K20MAP3K7 | |
| SCHEMBL2283239 | 0.84 | DDR1 (0.74) | EGFRBRAFDDR1MAP3K20MAP3K7 | |
| SCHEMBL17208650 | 0.81 | MAPT (0.56) | MAPTKDM4E | |
| SCHEMBL17208616 | 0.81 | DDR1 (0.85) | EGFRBRAFDDR1MAP3K20MAP3K7 | |
| SCHEMBL17208640 | 0.80 | ABL1 (0.56) | EGFRBRAFABL1MAPTKMT2A | |
| SCHEMBL17208695 | 0.80 | RAD52 (0.62) | EGFRBRAFABL1MAPTKMT2A | |
| SCHEMBL17208651 | 0.80 | MAPK14 (0.69) | EGFRBRAFDDR1MAP3K20MAP3K7 | |
| SCHEMBL14702344 | 0.79 | DDR1 (0.83) | EGFRBRAFDDR1MAP3K20MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |