Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 11/20 | 0.55 |
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14689713 | 0.94 | DDR2 (0.60) | PIKFYVECSF1RKITDDR1DDR2 | |
| SCHEMBL4790008 | 0.86 | BRAF (0.62) | PIKFYVEBRAFCSF1RKITDDR1 | |
| SCHEMBL17208612 | 0.85 | MAPK14 (0.53) | PIKFYVEBRAFCSF1RKITLCK | |
| SCHEMBL14704746 | 0.83 | DDR2 (0.58) | CSF1RKITDDR1DDR2LCK | |
| SCHEMBL3139304 | 0.80 | BMX (0.57) | BRAFCSF1RKITDDR1DDR2 | |
| SCHEMBL2283239 | 0.80 | DDR1 (0.74) | BRAFCSF1RKITDDR1 | |
| SCHEMBL14702344 | 0.80 | DDR1 (0.83) | BRAFDDR1RAF1 | |
| SCHEMBL17208650 | 0.80 | MAPT (0.56) | — | |
| SCHEMBL4790220 | 0.80 | LCK (0.62) | PIKFYVEBRAFCSF1RKITDDR1 | |
| SCHEMBL22457384 | 0.79 | MAPK14 (0.61) | BRAFCSF1RKITLCKRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |