Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | CSK | P41240 | 1/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.53 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 8/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | BTK | Q06187 | 4/20 | 0.49 |
| ▸ | CSF1R | P07333 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17243859 | 0.89 | MAPT (0.51) | MAPK14MAP3K7CSKMAP4K2BRAF | |
| SCHEMBL17208652 | 0.85 | PIKFYVE (0.56) | PIKFYVEBRAFCYP2C9LCKBTK | |
| SCHEMBL4790008 | 0.81 | BRAF (0.62) | MAPK14PIKFYVEBRAFCYP2C9LCK | |
| SCHEMBL14689713 | 0.81 | DDR2 (0.60) | MAPK14PIKFYVELCKCSF1RKIT | |
| SCHEMBL16581617 | 0.78 | CSK (0.63) | MAPK14MAP3K7CSKMAP4K2PIKFYVE | |
| SCHEMBL16581618 | 0.78 | CSK (0.63) | MAPK14MAP3K7CSKMAP4K2PIKFYVE | |
| SCHEMBL17208739 | 0.77 | LCK (0.58) | MAPK14BRAFCYP2C9LCKBTK | |
| SCHEMBL22457384 | 0.76 | MAPK14 (0.61) | MAPK14BRAFLCKCSF1RKIT | |
| SCHEMBL17537416 | 0.76 | PIKFYVE (0.51) | MAPK14MAP3K7MAP4K2PIKFYVEBRAF | |
| SCHEMBL14689711 | 0.75 | KDR (0.50) | MAPK14CSKPIKFYVEBRAFLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |