Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 18/20 | 0.59 |
| ▸ | KCNQ2 | O43526 | 18/20 | 0.59 |
| ▸ | KCNE1 | P15382 | 15/20 | 0.59 |
| ▸ | KCNQ1 | P51787 | 15/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600539 | 0.84 | KMT2A (0.63) | ALDH1A1 | |
| SCHEMBL1721583 | 0.83 | KCNQ3 (0.46) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL1720439 | 0.82 | KCNQ3 (0.45) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL1720440 | 0.82 | KCNQ3 (0.45) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL7514511 | 0.81 | KCNQ3 (0.60) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL4599740 | 0.79 | PRKCI (0.67) | ALDH1A1 | |
| SCHEMBL447449 | 0.78 | NAPRT (0.51) | ALDH1A1 | |
| SCHEMBL6106141 | 0.77 | KCNQ3 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL14083622 | 0.76 | TRPV1 (0.56) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL445818 | 0.76 | EGLN1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406265-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010102778-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2010-09-16 | — | — | WO | disclosed |
| US-20100234419-A1 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234419-A1 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | KCNQ1, KCNQ2, KCNQ3 | KCNQ3 3/4885KCNQ2 2/4885KCNE1 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.