Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | ROS1 | P08922 | 2/20 | 0.43 |
| ▸ | MARK3 | P27448 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9966373 | 0.89 | CD274 (0.42) | CD274RIPK1MAP4K4PLK4ROS1 | |
| SCHEMBL9940355 | 0.87 | ABL1 (0.44) | CD274RIPK1MAP4K4PLK4ROS1 | |
| SCHEMBL14295931 | 0.86 | CD274 (0.42) | CD274RIPK1MAP4K4PLK4ROS1 | |
| SCHEMBL9966364 | 0.86 | GSK3B (0.49) | CD274RIPK1MAP4K4PLK4ROS1 | |
| SCHEMBL9966465 | 0.84 | CDK8 (0.43) | CD274RIPK1MAP4K4PLK4ROS1 | |
| SCHEMBL17210407 | 0.83 | CD274 (0.41) | CD274RIPK1MAP4K4PLK4ROS1 | |
| SCHEMBL9966527 | 0.77 | PIK3CD (0.48) | RIPK1MAP4K4PLK4ROS1MARK3 | |
| SCHEMBL9966272 | 0.76 | HDAC1 (0.47) | IDO1RIPK1MAP4K4PLK4ROS1 | |
| SCHEMBL9966477 | 0.76 | CDK8 (0.46) | RIPK1MAP4K4PLK4ROS1MARK3 | |
| SCHEMBL9966566 | 0.74 | ABL1 (0.41) | MAP4K4HDAC1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651930-B1 | BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INT (DE) | 2015-10-28 | — | — | EP | disclosed |