Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940355 | 0.90 | ABL1 (0.44) | CD274PIK3C3HDAC1POLBRIPK1 | |
| SCHEMBL14295931 | 0.84 | CD274 (0.42) | CD274PIK3C3RIPK1PLK4JAK2 | |
| SCHEMBL17209602 | 0.83 | IDO1 (0.45) | CD274PIK3C3HDAC1RIPK1PLK4 | |
| SCHEMBL9966373 | 0.81 | CD274 (0.42) | CD274PIK3C3HDAC1POLBRIPK1 | |
| SCHEMBL9966364 | 0.79 | GSK3B (0.49) | CD274PIK3C3HDAC1POLBRIPK1 | |
| SCHEMBL9966465 | 0.79 | CDK8 (0.43) | CD274HDAC1POLBRIPK1PLK4 | |
| SCHEMBL17210412 | 0.78 | HDAC1 (0.41) | HDAC1MAP4K4CFTR | |
| SCHEMBL9966566 | 0.77 | ABL1 (0.41) | HDAC1POLBMAP4K4CTPS1ABL1 | |
| SCHEMBL9966562 | 0.76 | MAP4K4 (0.44) | HDAC1POLBMAP4K4CTPS1PIK3CA | |
| SCHEMBL9940475 | 0.74 | HDAC1 (0.43) | HDAC1CTPS1ABL1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651930-B1 | BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INT (DE) | 2015-10-28 | — | — | EP | disclosed |