Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DNM2 | P50570 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15114903 | 0.86 | EGFR (0.46) | EGFRL3MBTL1DNM2HRH4HCAR3 | |
| SCHEMBL10188164 | 0.84 | EGFR (0.49) | EGFRL3MBTL1DNM2HRH4ADRA2A | |
| SCHEMBL374260 | 0.84 | EGFR (0.53) | EGFRL3MBTL1DNM2HCAR3MEN1 | |
| SCHEMBL19928665 | 0.82 | HRH4 (0.49) | EGFRL3MBTL1DNM2HRH4MEN1 | |
| SCHEMBL8346152 | 0.81 | CYP2C19 (0.44) | EGFRL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL21016525 | 0.81 | EGFR (0.43) | EGFRL3MBTL1DNM2HRH4HCAR3 | |
| SCHEMBL22725623 | 0.81 | EGFR (0.43) | EGFRL3MBTL1DNM2HRH4HCAR3 | |
| SCHEMBL22644598 | 0.80 | CHEK1 (0.42) | EGFRDNM2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL2176219 | 0.78 | EGFR (0.67) | EGFRMEN1KMT2ATP53CYP1A2 | |
| SCHEMBL21016726 | 0.78 | EGFR (0.41) | EGFRL3MBTL1DNM2HRH4GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015164614-A1 | JANUS KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-10-29 | — | — | WO | disclosed |