Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 10/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5392226 | 0.88 | PDK4 (0.46) | ADORA1PDK4GRM5GRM1NAMPT | |
| SCHEMBL1721731 | 0.83 | CYP4F2 (0.40) | ALDH1A1L3MBTL1 | |
| SCHEMBL597913 | 0.82 | PDK4 (0.45) | ADORA1PDK4GRM5GRM1NAMPT | |
| SCHEMBL4532704 | 0.82 | PDK4 (0.46) | ADORA1PDK4GRM5GRM1NAMPT | |
| SCHEMBL12566963 | 0.82 | PDK4 (0.48) | ADORA1PDK4GRM5GRM1NAMPT | |
| SCHEMBL7677696 | 0.81 | PDK4 (0.44) | ADORA1PDK4GRM5GRM1NAMPT | |
| SCHEMBL7987553 | 0.81 | PDK4 (0.46) | ADORA1PDK4GRM5GRM1NAMPT | |
| SCHEMBL23852710 | 0.80 | ADORA1 (0.45) | ADORA1PDK4GRM5GRM1NAMPT | |
| SCHEMBL2002272 | 0.79 | PDK4 (0.48) | ADORA1PDK4GRM5GRM1NAMPT | |
| SCHEMBL12931062 | 0.78 | ADORA1 (0.53) | ADORA1ALDH1A1GLAPDK4GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406251-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103334-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |