Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.55 |
| ▸ | PDE4A | P27815 | 10/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14934301 | 0.91 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL10196382 | 0.83 | SYK (0.67) | PDE4DPDE4BPDE4APDE4CSYK | |
| SCHEMBL14320848 | 0.81 | PDE4D (0.55) | PDE4DPDE4BPDE4APDE4CSYK | |
| SCHEMBL12548302 | 0.79 | SYK (0.44) | PDE4DPDE4BPDE4APDE4CSYK | |
| SCHEMBL1613268 | 0.79 | SYK (0.44) | PDE4DPDE4BPDE4APDE4CSYK | |
| SCHEMBL882334 | 0.79 | PDE4A (0.59) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL28373126 | 0.78 | ALDH1A1 (0.58) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL523941 | 0.78 | PDE4D (0.52) | PDE4DPDE4BPDE4APDE4CSYK | |
| SCHEMBL15595689 | 0.77 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL274889 | 0.76 | SYK (0.42) | PDE4DPDE4BPDE4APDE4CSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528915-B1 | SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS SYK KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2015-10-28 | — | — | EP | disclosed |