Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 0.56 |
| ▸ | CYBB | P04839 | 10/20 | 0.43 |
| ▸ | NOX5 | Q96PH1 | 10/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 10/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215373 | 0.85 | NOX4 (0.65) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2219067 | 0.76 | NOX4 (0.69) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2218081 | 0.72 | NOX4 (0.81) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2217716 | 0.72 | NOX4 (1.00) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2218127 | 0.72 | NOX4 (1.00) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2218260 | 0.71 | NOX4 (0.85) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2219182 | 0.71 | NOX4 (0.78) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2219467 | 0.70 | NOX4 (0.76) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2217762 | 0.70 | NOX4 (0.69) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2218152 | 0.69 | NOX4 (0.75) | NOX4CYBBNOX5NOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2674160-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2015-10-28 | — | — | EP | disclosed |