Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.57 |
| ▸ | CYBB | P04839 | 8/20 | 0.51 |
| ▸ | NOX1 | Q9Y5S8 | 7/20 | 0.51 |
| ▸ | NOX5 | Q96PH1 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214424 | 0.85 | NOX4 (0.65) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL2217504 | 0.83 | NOX4 (0.62) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL2216211 | 0.82 | NOX4 (0.61) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL12441697 | 0.81 | NOX4 (0.84) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL2217794 | 0.81 | NOX4 (0.60) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL3609614 | 0.80 | NOX4 (0.63) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL2218410 | 0.78 | NOX4 (0.85) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL2218801 | 0.78 | NOX4 (0.60) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL14931743 | 0.76 | NOX4 (0.75) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 | |
| SCHEMBL29522756 | 0.76 | NOX4 (0.75) | NOX4CYP2C9CYP2C19CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2674160-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2015-10-28 | — | — | EP | disclosed |