Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.64 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721186 | 1.00 | CYP11B2 (0.64) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL1721803 | 1.00 | CYP11B2 (0.64) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL1721183 | 1.00 | CYP11B2 (0.64) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL1721801 | 1.00 | CYP11B2 (0.64) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL3095618 | 0.90 | CYP11B2 (0.58) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL27866413 | 0.90 | CYP11B2 (0.58) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL3091962 | 0.90 | CYP11B2 (0.58) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL30434052 | 0.84 | CYP11B2 (0.88) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL26154135 | 0.84 | CYP11B2 (0.88) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 | |
| SCHEMBL1721414 | 0.80 | CYP11B2 (0.64) | CYP11B2CHRNB2CHRNA7CHRNA4CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406266-B1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | KYORIN SEIYAKU KK (JP) | 2013-12-25 | — | — | EP | disclosed |
| EP-2406266-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceutical Co., Ltd. (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-8071591-B2 | 7-cycloalkylaminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-12-06 | — | — | US | disclosed |
| US-8071591-B2 | 7-cycloalkylaminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-12-06 | — | — | US | disclosed |
| US-8071591-B2 | 7-cycloalkylaminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-12-06 | — | — | US | disclosed |
| WO-2010104205-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010104205-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
| US-20100234367-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceuticals Co. Ltd | 2010-09-16 | — | — | US | disclosed |
| US-20100234367-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceuticals Co. Ltd | 2010-09-16 | — | — | US | disclosed |
| US-20100234367-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceuticals Co. Ltd | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234367-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | GSK3B, GSK3A, GSKIP | CYP11B2 341/4885CHRNB2 2894/4885CHRNA7 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.