Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | AHCY | P23526 | 1/20 | 0.46 |
| ▸ | PDE8A | O60658 | 7/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20059153 | 0.85 | CDK1 (0.46) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL13981871 | 0.81 | CDK1 (0.49) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL29325429 | 0.81 | CDK1 (0.46) | CDK1AHCYPDE8APDE4DPDE2A | |
| SCHEMBL14457638 | 0.79 | PDE8A (0.47) | CDK1AHCYPDE8APDE4DPDE2A | |
| SCHEMBL26349114 | 0.78 | CDK1 (0.58) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL29316547 | 0.77 | CDK1 (0.48) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL14326922 | 0.77 | CDK5 (0.36) | CDK1AHCYPDE8APDE4DPDE2A | |
| SCHEMBL22402774 | 0.77 | ADORA2A (0.62) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL10062072 | 0.75 | CDK1 (0.46) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL25566773 | 0.75 | CDK1 (0.46) | CDK1PDE8APDE4DPDE2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937420-A1 | Method for the synthesis of clofarabine | Synbias Pharma AG (CH) | 2015-10-28 | — | — | EP | disclosed |