Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | FRK | P42685 | 1/20 | 0.49 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721324 | 1.00 | MAPT (0.50) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL13004729 | 0.97 | MAPT (0.51) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL10198704 | 0.91 | L3MBTL1 (0.56) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL426316 | 0.91 | L3MBTL1 (0.56) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL426317 | 0.91 | L3MBTL1 (0.56) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL10196654 | 0.88 | MAPT (0.53) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL428754 | 0.88 | MAPT (0.53) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL428753 | 0.88 | MAPT (0.53) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL1617306 | 0.87 | PIKFYVE (0.54) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL1617304 | 0.87 | PIKFYVE (0.54) | MAPTGAAMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458687-B1 | PYRIMIDINE COMPOUNDS AS INTERLEUKIN-12 (IL-12) INHIBITORS | SYNTA PHARMACEUTICALS CORP (US) | 2012-01-11 | — | — | EP | claimed |