Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DDX3X | O00571 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799281 | 0.72 | KMT2A (0.49) | KMT2AMEN1PABPC1KDM4ELMNA | |
| SCHEMBL799159 | 0.70 | PIK3CG (0.47) | KMT2AMEN1PABPC1 | |
| SCHEMBL798680 | 0.69 | RIPK1 (0.48) | KMT2AMEN1PABPC1 | |
| SCHEMBL172085 | 0.68 | ABL1 (0.49) | KMT2AMEN1PABPC1KDM4ENPC1 | |
| SCHEMBL798733 | 0.68 | PIK3CG (0.61) | KMT2AMEN1PABPC1KDM4ENPC1 | |
| SCHEMBL14517911 | 0.63 | KDM4E (0.73) | KMT2AMEN1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL11051398 | 0.61 | KMT2A (0.53) | KMT2AMEN1KDM4EL3MBTL1LMNA | |
| SCHEMBL798739 | 0.61 | KDM4E (0.41) | KMT2AMEN1PABPC1KDM4EPPIA | |
| SCHEMBL11051369 | 0.58 | GAA (0.56) | KMT2AMEN1KDM4EL3MBTL1NPC1 | |
| SCHEMBL9297476 | 0.57 | KMT2A (0.75) | KMT2AMEN1PABPC1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426135-A1 | UREA DERIVATIVE HAVING PI3K INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |