Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.42 |
| ▸ | GRK6 | P43250 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | CTSA | P10619 | 3/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18539836 | 0.91 | PRMT1 (0.43) | STK17BPRMT1FFAR1FFAR4DHODH | |
| SCHEMBL17214751 | 0.87 | GRK6 (0.53) | GRK6MAPT | |
| SCHEMBL17214802 | 0.85 | MAPT (0.45) | GRK6FFAR1CTSAMAPT | |
| SCHEMBL17215002 | 0.85 | GRK6 (0.41) | GRK6FFAR4SLC13A5MAPT | |
| SCHEMBL17214809 | 0.85 | GRK6 (0.53) | GRK6MAPT | |
| SCHEMBL17214733 | 0.84 | S1PR1 (0.41) | STK17BFFAR1 | |
| SCHEMBL17214798 | 0.84 | MAOB (0.43) | GRK6FFAR1 | |
| SCHEMBL17214748 | 0.83 | EIF4A1 (0.45) | GRK6CTSASLC13A5MAPT | |
| SCHEMBL17214826 | 0.83 | DHODH (0.43) | STK17BFFAR1FFAR4DHODHCTSA | |
| SCHEMBL17214865 | 0.83 | NR4A2 (0.47) | GRK6FFAR1FFAR4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902739-B2 | Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2018-02-27 | — | — | US | disclosed |
| US-9902739-B2 | Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2018-02-27 | — | — | US | disclosed |
| US-20170050979-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-02-23 | — | — | US | disclosed |
| US-20170050979-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-02-23 | — | — | US | disclosed |
| WO-2015164411-A9 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2016-05-26 | — | — | WO | disclosed |
| WO-2015164411-A2 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050979-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES | GRK6, GRK2, GRK3 | STK17B 477/4885PRMT1 2184/4885GRK6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.