Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.39 |
| ▸ | GCK | P35557 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799149 | 0.91 | LMNA (0.43) | LMNAMEN1KMT2APIK3CGP2RY1 | |
| SCHEMBL799343 | 0.89 | LMNA (0.42) | LMNAMEN1KMT2APIK3CGGCK | |
| SCHEMBL799148 | 0.84 | LMNA (0.43) | LMNAMEN1KMT2APIK3CGP2RY1 | |
| SCHEMBL805072 | 0.84 | LMNA (0.44) | LMNAMEN1KMT2APIK3CGP2RY1 | |
| SCHEMBL799225 | 0.84 | PIK3CG (0.49) | LMNAMEN1KMT2APIK3CGGCK | |
| SCHEMBL799051 | 0.84 | PIK3CG (0.47) | LMNAMEN1KMT2APIK3CGGCK | |
| SCHEMBL798945 | 0.83 | P2RY1 (0.40) | LMNAMEN1KMT2APIK3CGP2RY1 | |
| SCHEMBL798946 | 0.83 | P2RY1 (0.40) | LMNAMEN1KMT2APIK3CGP2RY1 | |
| SCHEMBL799264 | 0.83 | PIK3CG (0.43) | LMNAMEN1KMT2APIK3CGP2RY1 | |
| SCHEMBL798914 | 0.83 | PIK3CG (0.51) | LMNAMEN1KMT2APIK3CGP2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426135-A1 | UREA DERIVATIVE HAVING PI3K INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |