Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | STK16 | O75716 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17220317 | 0.96 | AURKA (0.39) | PDE2AAURKAJAK2JAK1TYK2 | |
| Trifluoroacetic Acid SCHEMBL17220085 | 0.92 | AURKA (0.40) | AURKAJAK2JAK1TYK2KDR | |
| SCHEMBL13579634 | 0.91 | AURKA (0.46) | PDE2AAURKAJAK2JAK1TYK2 | |
| Trifluoroacetic Acid SCHEMBL17220420 | 0.88 | AURKA (0.42) | AURKAJAK2JAK1TYK2KDR | |
| SCHEMBL13579643 | 0.87 | AURKA (0.46) | PDE2AAURKAJAK2JAK1TYK2 | |
| Trifluoroacetic Acid SCHEMBL17220344 | 0.86 | KDR (0.45) | PDE2AAURKAJAK2JAK1TYK2 | |
| Trifluoroacetic Acid SCHEMBL17219987 | 0.85 | AURKA (0.41) | AURKAJAK2JAK1TYK2KDR | |
| Trifluoroacetic Acid SCHEMBL17220129 | 0.83 | KDR (0.42) | AURKAJAK2JAK1TYK2KDR | |
| SCHEMBL13579642 | 0.82 | AURKA (0.47) | AURKAJAK2JAK1TYK2KDR | |
| Trifluoroacetic Acid SCHEMBL17219952 | 0.82 | AURKA (0.42) | AURKAJAK2JAK1TYK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299821-B1 | TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2015-11-04 | — | — | EP | disclosed |