Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | TUBB1 | Q9H4B7 | 13/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 12/20 | 0.54 |
| ▸ | TUBB | P07437 | 12/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 12/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 12/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 12/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 12/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 12/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 12/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 12/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 12/20 | 0.54 |
| ▸ | TUBA1A | Q71U36 | 12/20 | 0.54 |
| ▸ | TUBA1C | Q9BQE3 | 12/20 | 0.54 |
| ▸ | TUBB6 | Q9BUF5 | 12/20 | 0.54 |
| ▸ | TUBB2B | Q9BVA1 | 12/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540717 | 1.00 | PTGS1 (0.59) | PTGS1TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL17224400 | 1.00 | PTGS1 (0.59) | PTGS1TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL18528457 | 0.87 | PTGS1 (0.47) | PTGS1TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL17224294 | 0.87 | PTGS1 (0.47) | PTGS1TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL17224265 | 0.85 | PTGS1 (0.56) | PTGS1MEN1NPC1HSP90AA1GAA | |
| SCHEMBL17224266 | 0.85 | PTGS1 (0.56) | PTGS1MEN1NPC1HSP90AA1GAA | |
| SCHEMBL18540732 | 0.85 | PTGS1 (0.56) | PTGS1MEN1NPC1HSP90AA1GAA | |
| SCHEMBL17224380 | 0.85 | PTGS1 (0.51) | PTGS1TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL17224381 | 0.85 | PTGS1 (0.51) | PTGS1TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL17224354 | 0.82 | CYP3A4 (0.55) | PTGS1TUBB1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137554-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | Ecole Normale Superieure De Lyon (FR) | 2017-03-08 | — | — | EP | claimed |
| US-20170051149-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2017-02-23 | — | — | US | claimed |
| WO-2015166295-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2015-11-05 | — | — | WO | claimed |
| EP-3137554-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | Ecole Normale Superieure De Lyon (FR) | 2017-03-08 | — | — | EP | disclosed |
| US-20170051149-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2017-02-23 | — | — | US | disclosed |
| US-20170051149-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2017-02-23 | — | — | US | disclosed |
| US-20170051149-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2017-02-23 | — | — | US | disclosed |
| WO-2015166295-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2015-11-05 | — | — | WO | disclosed |