SCHEMBL17224348

SCHEMBL17224348

COc1cc(O)ccc1N=Nc1cc(OC)c(OC)c(OC)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.53
CYP3A4 P08684 1/20 0.53
MAOB P27338 1/20 0.46
EGFR P00533 1/20 0.42
PHLPP2 Q6ZVD8 1/20 0.41
CALCRL Q16602 1/20 0.41
TUBB4A P04350 4/20 0.41
TUBB P07437 4/20 0.41
TUBA3C P0DPH7 4/20 0.41
TUBA1B P68363 4/20 0.41
TUBA4A P68366 4/20 0.41
TUBB4B P68371 4/20 0.41
TUBB3 Q13509 4/20 0.41
TUBB2A Q13885 4/20 0.41
TUBB8 Q3ZCM7 4/20 0.41
TUBA3E Q6PEY2 4/20 0.41
TUBA1A Q71U36 4/20 0.41
TUBA1C Q9BQE3 4/20 0.41
TUBB6 Q9BUF5 4/20 0.41
TUBB2B Q9BVA1 4/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17224346 1.00 MAPT (0.53) MAPTCYP3A4MAOBEGFRPHLPP2
SCHEMBL18540741 0.89 EGFR (0.57) MAPTCYP3A4MAOBEGFRCALCRL
SCHEMBL17224386 0.89 EGFR (0.57) MAPTCYP3A4MAOBEGFRCALCRL
SCHEMBL17224387 0.89 EGFR (0.57) MAPTCYP3A4MAOBEGFRCALCRL
SCHEMBL18540744 0.88 MAPT (0.46) MAPTCYP3A4MAOBEGFRCALCRL
SCHEMBL17224281 0.86 MAPT (0.44) MAPTCYP3A4MAOBEGFRCALCRL
SCHEMBL17224280 0.86 MAPT (0.44) MAPTCYP3A4MAOBEGFRCALCRL
SCHEMBL17224354 0.83 CYP3A4 (0.55) MAPTCYP3A4EGFRTUBB4ATUBB
SCHEMBL17224357 0.83 CYP3A4 (0.55) MAPTCYP3A4EGFRTUBB4ATUBB
SCHEMBL11146552 0.82 MEN1 (0.55) MAPTMAOBEGFRPHLPP2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3137554-A1 AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS Ecole Normale Superieure De Lyon (FR) 2017-03-08 EP disclosed
US-20170051149-A1 AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS ECOLE NORMALE SUPERIEURE DE LYON (FR) 2017-02-23 US disclosed
US-20170051149-A1 AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS ECOLE NORMALE SUPERIEURE DE LYON (FR) 2017-02-23 US disclosed
WO-2015166295-A1 AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS ECOLE NORMALE SUPERIEURE DE LYON (FR) 2015-11-05 WO disclosed