Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.43 |
| ▸ | TUBB | P07437 | 4/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17224386 | 1.00 | EGFR (0.57) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL17224387 | 1.00 | EGFR (0.57) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL18540740 | 0.89 | NPC1 (0.59) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL17224366 | 0.89 | NPC1 (0.59) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL17224364 | 0.89 | NPC1 (0.59) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL17224346 | 0.89 | MAPT (0.53) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL17224348 | 0.89 | MAPT (0.53) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL18540744 | 0.86 | MAPT (0.46) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL17224281 | 0.85 | MAPT (0.44) | EGFRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL17224280 | 0.85 | MAPT (0.44) | EGFRMAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170051149-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2017-02-23 | — | — | US | disclosed |