Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | LDLR | P01130 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388399 | 0.84 | KMT2A (0.40) | SMN1; SMN2KMT2AMEN1POLBHDAC6 | |
| SCHEMBL1725661 | 0.84 | EPHX1 (0.40) | SMN1; SMN2KMT2AMEN1POLBHDAC6 | |
| SCHEMBL1710677 | 0.83 | KMT2A (0.38) | SMN1; SMN2KMT2AMEN1POLBHDAC6 | |
| SCHEMBL3390536 | 0.83 | EPHX1 (0.38) | SMN1; SMN2KMT2AMEN1LDLRALDH1A1 | |
| SCHEMBL1725422 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL1710545 | 0.78 | BCHE (0.35) | KMT2AMEN1EPHX2 | |
| SCHEMBL1726498 | 0.76 | KMT2A (0.35) | SMN1; SMN2KMT2AMEN1HDAC6KCNH2 | |
| SCHEMBL1710420 | 0.76 | HAO1 (0.37) | KMT2AMEN1POLBRAB9ANPC1 | |
| SCHEMBL2150642 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1POLBHDAC6 | |
| SCHEMBL2150853 | 0.74 | MEN1 (0.46) | SMN1; SMN2KMT2AMEN1HDAC6RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |