Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 4/20 | 0.37 |
| ▸ | CES1 | P23141 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722159 | 0.85 | NQO2 (0.39) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL1710775 | 0.84 | HSD17B3 (0.39) | SMN1; SMN2CES2CES1THRATHRB | |
| SCHEMBL1722558 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL2151087 | 0.74 | HDAC11 (0.49) | SMN1; SMN2NAAAALDH1A1MAPTGAA | |
| SCHEMBL1710650 | 0.73 | KMT2A (0.45) | SMN1; SMN2L3MBTL1THRATHRBALDH1A1 | |
| SCHEMBL2150676 | 0.73 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1GAAHPGD | |
| SCHEMBL2151211 | 0.71 | THRA (0.46) | SMN1; SMN2LMNATHRAALDH1A1GAA | |
| SCHEMBL22982704 | 0.69 | MAPT (0.58) | SMN1; SMN2CES1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL16031988 | 0.69 | TP53BP1 (0.46) | L3MBTL1LMNAALDH1A1MAPT | |
| SCHEMBL1724523 | 0.69 | GPR88 (0.36) | L3MBTL1ALDH1A1MAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |