Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 11/20 | 0.42 |
| ▸ | CSF1R | P07333 | 5/20 | 0.41 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 4/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857561 | 0.84 | BRAF (0.48) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL2858679 | 0.83 | KDR (0.48) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL2855913 | 0.83 | BTK (0.50) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL2855661 | 0.83 | KDR (0.53) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL2858206 | 0.81 | KDR (0.51) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL13185061 | 0.79 | KDR (0.44) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL2859286 | 0.78 | WNT3A (0.47) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL13184980 | 0.76 | LCK (0.45) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL13184976 | 0.76 | KDR (0.40) | ALDH1A1KDRTEKBRAFCSF1R | |
| SCHEMBL2857374 | 0.76 | BRAF (0.53) | KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |