Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 3/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PARG | Q86W56 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28713447 | 0.85 | SMN1; SMN2 (0.63) | UCHL1USP30ALDH1A1MMP2MMP9 | |
| SCHEMBL1711795 | 0.81 | UCHL1 (0.54) | UCHL1USP30ALDH1A1MMP2MMP9 | |
| SCHEMBL1723222 | 0.81 | UCHL1 (0.54) | UCHL1USP30ALDH1A1MMP2MMP9 | |
| SCHEMBL23052370 | 0.79 | KDM4E (0.76) | UCHL1USP30ALDH1A1MMP2MMP9 | |
| SCHEMBL2195659 | 0.78 | MAP2K4 (0.47) | ALDH1A1SMN1; SMN2SLC22A12IDH2LMNA | |
| SCHEMBL2195671 | 0.78 | MAP2K4 (0.47) | ALDH1A1SMN1; SMN2SLC22A12IDH2LMNA | |
| SCHEMBL2195764 | 0.78 | MAP2K4 (0.47) | ALDH1A1SMN1; SMN2SLC22A12IDH2LMNA | |
| SCHEMBL16863965 | 0.78 | UCHL1 (0.49) | UCHL1USP30ALDH1A1MMP2MMP9 | |
| SCHEMBL12418061 | 0.78 | KDM4E (0.73) | UCHL1USP30ALDH1A1MMP2MMP9 | |
| SCHEMBL12418055 | 0.78 | KDM4E (0.73) | UCHL1USP30ALDH1A1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344449-A1 | ARYL-PHENYL-SULFONAMIDO-CYCLOALKYL COMPOUNDS AND THEIR USE | Pimco 2664 Limited (GB) | 2011-07-20 | — | — | EP | disclosed |