Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.55 |
| ▸ | PRKCG | P05129 | 2/20 | 0.55 |
| ▸ | PRKCB | P05771 | 2/20 | 0.55 |
| ▸ | PRKCA | P17252 | 2/20 | 0.55 |
| ▸ | PRKCH | P24723 | 2/20 | 0.55 |
| ▸ | PRKCI | P41743 | 2/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | PRKACG | P22612 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18428229 | 1.00 | CHRM1 (0.61) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL17228389 | 0.94 | CYP3A4 (0.57) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL17228328 | 0.93 | CHRM1 (0.57) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL18428243 | 0.91 | CHRM1 (0.55) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL17228498 | 0.88 | CHRM1 (0.55) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL18428307 | 0.88 | CHRM1 (0.55) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL17228297 | 0.85 | CHRM1 (0.53) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL987296 | 0.85 | ROCK2 (0.59) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL17228320 | 0.84 | CHRM1 (0.51) | CHRM1CYP3A4PRKD3PRKCGPRKCB | |
| SCHEMBL18428300 | 0.84 | CHRM1 (0.51) | CHRM1CYP3A4PRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138843-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | Medshine Discovery Inc. (CN) | 2017-03-08 | — | — | EP | disclosed |
| US-20170037050-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | MEDSHINE DISCOVERY INC. (CN) | 2017-02-09 | — | — | US | disclosed |
| US-20170037050-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | MEDSHINE DISCOVERY INC. (CN) | 2017-02-09 | — | — | US | disclosed |
| WO-2015165341-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | 南京明德新药研发股份有限公司 | 2015-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037050-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | ROCK1, ROCK2, CIT | CHRM1 3688/4885CYP3A4 2096/4885PRKD3 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.