Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | ITK | Q08881 | 3/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8258606 | 0.89 | MAPK8 (0.55) | MAPK8MAPK9MAPK10MAP3K11AAK1 | |
| SCHEMBL17229228 | 0.86 | AXL (0.56) | MAP3K11AAK1GSK3BKITBTK | |
| SCHEMBL4200987 | 0.82 | MAPK8 (0.60) | MAPK8MAPK9MAPK10MAP3K11AAK1 | |
| SCHEMBL8249652 | 0.82 | MAPK8 (0.60) | MAPK8MAPK9MAPK10MAP3K11AAK1 | |
| SCHEMBL4193535 | 0.82 | AAK1 (0.67) | MAPK8MAPK9MAPK10MAP3K11AAK1 | |
| SCHEMBL8298203 | 0.81 | MAPK8 (0.66) | MAPK8MAPK9MAPK10MAP3K11AAK1 | |
| SCHEMBL11924765 | 0.81 | AAK1 (0.68) | MAPK8MAPK9MAPK10MAP3K11AAK1 | |
| SCHEMBL8254992 | 0.80 | AAK1 (0.55) | MAPK8MAPK9MAPK10MAP3K11AAK1 | |
| SCHEMBL8298204 | 0.79 | AAK1 (0.52) | MAPK8MAPK9MAPK10MAP3K11AAK1 | |
| SCHEMBL13753917 | 0.77 | MAPK8 (0.63) | MAPK8MAPK9MAPK10MAP3K11NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150313881-A1 | Therapeutic Methods for Type I Diabetes | UNIVERSITY OF MASSACHUSETTS | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150313881-A1 | Therapeutic Methods for Type I Diabetes | MAPK9, IAPP, RNASE1 | MAPK8 25/4885MAPK9 1/4885MAPK10 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.