Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 20/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17229650 | 0.90 | RBP4 (0.78) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29813337 | 0.89 | RBP4 (0.76) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17222977 | 0.89 | RBP4 (0.76) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30949119 | 0.87 | RBP4 (1.00) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17505314 | 0.87 | RBP4 (1.00) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17222994 | 0.86 | RBP4 (1.00) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17229651 | 0.85 | RBP4 (0.79) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL26376055 | 0.83 | RBP4 (0.82) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17505267 | 0.83 | RBP4 (1.00) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30949122 | 0.83 | RBP4 (1.00) | RBP4CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230241049-A1 | RBP4 ANTAGONISTS FOR TREATMENT AND PREVENTION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND GOUT | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-08-03 | — | — | US | disclosed |
| US-11649240-B2 | Substituted 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-05-16 | — | — | US | disclosed |
| US-20180030060-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-02-01 | — | — | US | disclosed |
| US-9777010-B2 | Substituted 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160368925-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-12-22 | — | — | US | disclosed |
| US-9434727-B2 | Substituted 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-09-06 | — | — | US | disclosed |
| US-20150315197-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315197-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HRH4, HRH3, HRH2 | RBP4 1884/4885CYP3A4 117/4885CYP2D6 317/4885 |
| US-20160368925-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HRH4, HRH3, HRH2 | RBP4 1950/4885CYP3A4 123/4885CYP2D6 327/4885 |
| US-20180030060-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HRH4, HRH3, HRH2 | RBP4 1884/4885CYP3A4 117/4885CYP2D6 317/4885 |
| US-20230241049-A1 | RBP4 ANTAGONISTS FOR TREATMENT AND PREVENTION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND GOUT | RBP4, RBP1, FABP1 | RBP4 1/4885CYP3A4 1171/4885CYP2D6 3828/4885 |
| US-11649240-B2 | Substituted 4-phenylpiperidines, their preparation and use | HRH4, HRH3, HRH2 | RBP4 1884/4885CYP3A4 117/4885CYP2D6 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.