Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18155326 | 1.00 | F2 (0.75) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL17231945 | 0.95 | F2 (0.76) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL17236162 | 0.86 | F2 (1.00) | F2 | |
| SCHEMBL17236225 | 0.84 | ALDH1A1 (0.54) | F2ALDH1A1F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL17222092 | 0.83 | F2 (0.89) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL23997702 | 0.82 | F2 (0.76) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL17236201 | 0.82 | ALDH1A1 (0.52) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL17222111 | 0.82 | F2 (0.51) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL17222108 | 0.82 | F2 (0.51) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL17231901 | 0.82 | F2 (0.79) | F2F10PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469608-B2 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-10-18 | — | — | US | disclosed |
| US-20150315141-A1 | Thrombin Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315141-A1 | Thrombin Inhibitors | F3, F2, F9 | F2 2/4885ALDH1A1 4066/4885F10 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.