Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.57 |
| ▸ | LMNA | P02545 | 8/20 | 0.57 |
| ▸ | POLB | P06746 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 13/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | HPGD | P15428 | 10/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.51 |
| ▸ | MITF | O75030 | 3/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 5/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 7/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13436799 | 0.90 | MAPT (0.70) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL17232454 | 0.83 | HPGD (0.58) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL19334391 | 0.82 | MAPT (0.51) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL13436906 | 0.75 | MAPT (0.59) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL13401763 | 0.71 | MAPT (0.65) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL5281834 | 0.68 | MAPT (0.74) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL5281823 | 0.68 | MAPT (0.73) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL5283971 | 0.66 | MAPT (0.89) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL6391137 | 0.66 | MAPT (0.71) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL17232450 | 0.64 | LIG1 (0.79) | MAPTLMNAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | LIG1, LIG4, LIG3 | MAPT 3367/4885LMNA 785/4885POLB 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.