Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 0.74 |
| ▸ | HTT | P42858 | 8/20 | 0.74 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.74 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.73 |
| ▸ | HPGD | P15428 | 10/20 | 0.73 |
| ▸ | MEN1 | O00255 | 9/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.73 |
| ▸ | MITF | O75030 | 3/20 | 0.73 |
| ▸ | BLM | P54132 | 2/20 | 0.73 |
| ▸ | XBP1 | P17861 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 7/20 | 0.69 |
| ▸ | POLB | P06746 | 4/20 | 0.69 |
| ▸ | PKM | P14618 | 5/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.69 |
| ▸ | RECQL | P46063 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5281823 | 0.89 | MAPT (0.73) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL5283971 | 0.87 | MAPT (0.89) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL6391137 | 0.87 | MAPT (0.71) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL8156930 | 0.86 | MAPT (0.71) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL5285308 | 0.84 | MAPT (0.66) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL5288929 | 0.83 | MAPT (0.78) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL5243197 | 0.82 | MAPT (1.00) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL13436799 | 0.78 | MAPT (0.70) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL14959208 | 0.78 | MAPT (0.69) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL13436906 | 0.71 | MAPT (0.59) | MAPTHTTAGTR1NTSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758873-A1 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | claimed |