Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.62 |
| ▸ | STK3 | Q13188 | 2/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.62 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.62 |
| ▸ | CLK2 | P49760 | 1/20 | 0.62 |
| ▸ | BLK | P51451 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 1/20 | 0.53 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | AKT2 | P31751 | 1/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5574942 | 0.90 | ROCK2 (0.69) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL3793015 | 0.90 | ROCK2 (0.64) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL1728904 | 0.90 | ROCK2 (0.64) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL1728902 | 0.90 | ROCK2 (0.64) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL3790618 | 0.86 | ROCK2 (0.72) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL877535 | 0.84 | ROCK2 (0.77) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL877970 | 0.83 | ROCK2 (0.76) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL877958 | 0.82 | ROCK2 (0.73) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL1724986 | 0.81 | ROCK2 (0.72) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL1724078 | 0.81 | ROCK2 (0.72) | ROCK2ROCK1CSNK2A1STK3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| EP-1865958-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | Surface Logix, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105081-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-10-05 | — | — | WO | disclosed |