Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180770 | 0.80 | HDAC3 (0.46) | CNR2SYKBTKHDAC3HDAC1 | |
| SCHEMBL29818135 | 0.70 | NPC1 (0.63) | BTKBLKSRCHDAC3HDAC1 | |
| SCHEMBL180787 | 0.69 | DGAT1 (0.64) | — | |
| SCHEMBL16546762 | 0.69 | DGAT1 (0.64) | — | |
| SCHEMBL13664059 | 0.69 | DGAT1 (0.64) | — | |
| SCHEMBL1736682 | 0.68 | GFRA3 (0.54) | CNR2SYKHDAC3HDAC1HDAC2 | |
| SCHEMBL180650 | 0.67 | DGAT1 (0.69) | TBK1 | |
| SCHEMBL1448287 | 0.67 | DGAT1 (0.50) | SYKHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5459434 | 0.67 | MEN1 (0.52) | SYKSRCTP53PDE4BPDE4D | |
| SCHEMBL1734253 | 0.67 | CSNK2A1 (0.54) | SYKHDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404905-A1 | New compounds | Novartis AG (CH) | 2012-01-11 | — | — | EP | disclosed |