SCHEMBL17237644

SCHEMBL17237644

CC(=O)Nc1ccc(O)c(N2CCO[C@H]([C@@H](O)C(=O)Nc3ccc(C(=N)N)cc3)C2=O)c1

nearest known ligand 0.67

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
F9 P00740 11/20 0.67
F10 P00742 8/20 0.38
F2 P00734 7/20 0.38
PLAU P00749 7/20 0.38
PLAT P00750 6/20 0.38
PLG P00747 2/20 0.36
HPN P05981 1/20 0.35
ITGB3 P05106 1/20 0.35
ITGA2B P08514 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7901577 0.87 F9 (0.70) F9F10F2PLAUPLAT
SCHEMBL1946988 0.87 F9 (0.86) F9F10F2PLAUHPN
Hydrochloric Acid SCHEMBL1439254 0.87 F9 (0.84) F9F10F2PLAUHPN
SCHEMBL1949864 0.86 F9 (0.83) F9F10F2
Hydrochloric Acid SCHEMBL1947433 0.85 F9 (0.81) F9F10F2
SCHEMBL1946901 0.82 F9 (0.77) F9F10F2PLAUPLAT
Hydrochloric Acid SCHEMBL1946303 0.82 F9 (0.76) F9F10F2PLAUPLAT
SCHEMBL1950249 0.81 F9 (0.69) F9F10F2PLAUHPN
SCHEMBL1948970 0.80 F9 (0.68) F9F10F2PLAUPLAT
Hydrochloric Acid SCHEMBL1947099 0.80 F9 (0.68) F9F10F2PLAUHPN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2373634-B1 MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS MOCHIDA PHARM CO LTD (JP) 2015-11-11 EP disclosed