Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 5/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249252 | 0.94 | TACR1 (0.41) | HTTKCNH2GRIN2BWNT3ATACR1 | |
| SCHEMBL17243391 | 0.89 | TRPV1 (0.49) | L3MBTL1HTTWNT3AADORA2AADORA1 | |
| SCHEMBL17243393 | 0.85 | WNT3A (0.48) | L3MBTL1HTTKCNH2GRIN2BWNT3A | |
| SCHEMBL248091 | 0.84 | HDAC4 (0.41) | WNT3A | |
| SCHEMBL248144 | 0.83 | TRPV1 (0.52) | L3MBTL1HTTWNT3AADORA2AADORA1 | |
| SCHEMBL248781 | 0.82 | WNT3A (0.41) | KCNH2GRIN2BWNT3A | |
| SCHEMBL247582 | 0.80 | WNT3A (0.50) | WNT3AADORA2AADORA1 | |
| SCHEMBL17243394 | 0.78 | TRPV1 (0.51) | L3MBTL1HTTKCNH2GRIN2BWNT3A | |
| SCHEMBL248044 | 0.78 | WNT3A (0.49) | HTTKCNH2GRIN2BWNT3ARAB9A | |
| SCHEMBL249965 | 0.76 | WNT3A (0.54) | WNT3AWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181235-B2 | Substituted pyridines for modulating the WNT signaling pathway | NOVARTIS AG (CH) | 2015-11-10 | — | — | US | disclosed |