Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17243910 | 0.89 | MAP3K14 (0.34) | ALDH1A1KDM4EMAPK8PKD1MAP3K14 | |
| SCHEMBL17243623 | 0.78 | ELANE (0.42) | ELANEALDH1A1ADORA1HTTKDM4E | |
| SCHEMBL17233527 | 0.77 | PDE4A (0.51) | ELANEALDH1A1ADORA1HTTKDM4E | |
| SCHEMBL17233520 | 0.72 | ELANE (0.44) | ELANEALDH1A1ADORA1HTTKDM4E | |
| SCHEMBL16532310 | 0.70 | ELANE (0.56) | ELANEALDH1A1ADORA1KDM4EHSD17B10 | |
| SCHEMBL17243618 | 0.68 | ELANE (0.52) | ELANEKDM4EBRD4 | |
| SCHEMBL17243924 | 0.67 | PDE4A (0.45) | PKD1MAP3K14 | |
| SCHEMBL17243915 | 0.65 | PDE4A (0.42) | PKD1MAP3K14 | |
| SCHEMBL17243622 | 0.64 | PDE4A (0.40) | ALDH1A1KDM4EMAPK8CA1CA2 | |
| SCHEMBL13070650 | 0.63 | ALDH1A1 (0.52) | ALDH1A1ADORA1HTTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181244-B1 | Substituted pyrido[2,3-c]pyridazin-4(1H)-ones as tumor necrosis factor alpha and phosphodiesterase 4 inhibitors | Xuanzhu Pharma Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |