Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 4/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | KDM4B | O94953 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855714 | 0.83 | KAT6A (0.54) | KAT6AFYNCDK8MAP4K4KDM5B | |
| SCHEMBL6164638 | 0.82 | KAT6A (0.54) | KAT6ACDK8KDM5BKDM4CKDM4A | |
| SCHEMBL31018816 | 0.81 | KDM4A (0.67) | KAT6AKDM5BKDM4AKDM4BKDM5C | |
| SCHEMBL4079387 | 0.81 | KDM4A (0.67) | KAT6AKDM5BKDM4AKDM4BKDM5C | |
| SCHEMBL13702375 | 0.79 | HDAC8 (0.68) | HDAC8HDAC6FYNCDK8MAP4K4 | |
| SCHEMBL4536161 | 0.76 | TP53 (0.49) | KAT6ANPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7389467 | 0.76 | SCN9A (0.48) | KAT6AHDAC6KDM5BKDM4AKDM4B | |
| SCHEMBL3037788 | 0.76 | HDAC8 (0.82) | HDAC8HDAC6CDK8MAP4K4NR4A2 | |
| SCHEMBL13407999 | 0.75 | MAPT (0.57) | HDAC8HDAC6NPC1MAPTRAB9A | |
| SCHEMBL12852604 | 0.75 | EGFR (0.49) | KAT6AABL1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403835-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | Pfizer Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100606-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2010-09-10 | — | — | WO | disclosed |