Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.70 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.63 |
| ▸ | TUBB | P07437 | 1/20 | 0.63 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.63 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.63 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.63 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.63 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.63 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.63 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.63 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.63 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.63 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.63 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.63 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.63 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720318 | 0.91 | MTNR1A (0.82) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL12302912 | 0.89 | MTNR1A (0.73) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL30605277 | 0.87 | MTNR1A (0.71) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL25938747 | 0.87 | MTNR1A (0.71) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL2449555 | 0.86 | F10 (0.64) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL31609680 | 0.85 | MTNR1A (0.72) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL8642683 | 0.84 | MTNR1A (0.71) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL8199064 | 0.84 | SMN1; SMN2 (0.64) | MTNR1AMTNR1BALDH1A1POLB | |
| SCHEMBL1724790 | 0.83 | F10 (0.61) | F10 | |
| SCHEMBL259383 | 0.81 | NPSR1 (0.78) | ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-01-18 | — | — | EP | disclosed |
| EP-0717739-A1 | BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007274-A1 | BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-03-16 | — | — | WO | disclosed |