Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 2/20 | 0.47 |
| ▸ | AOC1 | P19801 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL614610 | 0.90 | MKNK1 (0.49) | IL2AOC1AOC3MKNK1MKNK2 | |
| SCHEMBL614603 | 0.86 | IL2 (0.49) | IL2MKNK1MKNK2NCOA1NCOA3 | |
| SCHEMBL1725706 | 0.82 | IL2 (0.47) | IL2AOC1AOC3MKNK1MKNK2 | |
| SCHEMBL613989 | 0.81 | KDM6B (0.49) | IL2MKNK1MKNK2NCOA1NCOA3 | |
| SCHEMBL613187 | 0.79 | ALDH1A1 (0.54) | IL2MKNK1MKNK2NCOA1NCOA3 | |
| SCHEMBL29165231 | 0.79 | IL2 (0.47) | IL2MKNK1MKNK2NCOA1NCOA3 | |
| SCHEMBL1724875 | 0.79 | KDM4C (0.51) | IL2MKNK1MKNK2NCOA1NCOA3 | |
| SCHEMBL612008 | 0.78 | KDM4C (0.51) | IL2MKNK1MKNK2CYP3A4KDM4E | |
| SCHEMBL1724808 | 0.75 | KDM4C (0.53) | IL2MKNK1MKNK2CYP3A4CYP2C9 | |
| SCHEMBL5238765 | 0.72 | HDAC3 (0.66) | MKNK1MKNK2NCOA1NCOA3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403857-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101302-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-10 | — | — | WO | disclosed |