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Sugi Predict / Compounds / SCHEMBL1724849

SCHEMBL1724849

SCHEMBL1724849

CC(C)c1noc(N2CCC(CCCOc3cnc(N4C[C@H](NC(=O)O)[C@@H](N5CCCCC5=O)C4)nc3)CC2)n1

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 16/20 0.40
▸ GPR183 P32249 1/20 0.39
▸ KCNH2 Q12809 3/20 0.36
▸ ACACB O00763 1/20 0.34
▸ CYP4F2 P78329 1/20 0.31
▸ CYP4A11 Q02928 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1724851 1.00 GPR119 (0.40) GPR119GPR183KCNH2ACACBCYP4F2
SCHEMBL150987 0.92 GPR119 (0.39) GPR119GPR183KCNH2ACACB
SCHEMBL150986 0.92 GPR119 (0.39) GPR119GPR183KCNH2ACACB
SCHEMBL120032 0.87 GPR119 (0.42) GPR119GPR183KCNH2
SCHEMBL147767 0.87 GPR119 (0.42) GPR119GPR183KCNH2
SCHEMBL151482 0.84 GPR119 (0.34) GPR119GPR183KCNH2
SCHEMBL151484 0.84 GPR119 (0.34) GPR119GPR183KCNH2
SCHEMBL151483 0.84 GPR119 (0.34) GPR119GPR183KCNH2
SCHEMBL148829 0.82 GPR119 (0.35) GPR119GPR183KCNH2ACACB
SCHEMBL122219 0.78 DPP4 (0.41) GPR119GPR183KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2406251-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS Prosidion Limited (GB) 2012-01-18 — — EP disclosed
WO-2010103334-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2010-09-16 — — WO disclosed