SCHEMBL172495

SCHEMBL172495

C=CC(=O)Oc1ccc(N(c2ccc(C)cc2)c2ccc(-c3ccc(OC)cc3)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.46
LMNA P02545 5/20 0.44
GAA P10253 1/20 0.44
ACHE P22303 1/20 0.42
TP53 P04637 1/20 0.41
TGM2 P21980 1/20 0.40
BCL2A1 Q16548 2/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
MAPT P10636 1/20 0.39
RELA Q04206 1/20 0.39
HSP90AA1 P07900 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12149086 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT
SCHEMBL11987047 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT
SCHEMBL12149075 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT
SCHEMBL13051080 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT
SCHEMBL9915715 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT
SCHEMBL9915808 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT
SCHEMBL11938791 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT
SCHEMBL12149033 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT
SCHEMBL22148977 0.94 THRB (0.50) THRBLMNATP53TGM2BCL2A1
SCHEMBL2540869 0.94 THRB (0.50) THRBLMNAGAATGM2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1847881-B1 Image forming apparatus, image forming method, and process cartridge RICOH CO LTD (JP) 2012-03-07 EP disclosed