Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 20/20 | 0.65 |
| ▸ | TNKS2 | Q9H2K2 | 20/20 | 0.65 |
| ▸ | PARP1 | P09874 | 14/20 | 0.65 |
| ▸ | PARP2 | Q9UGN5 | 8/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17241097 | 0.89 | TNKS (0.67) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17241246 | 0.84 | TNKS (0.63) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17241107 | 0.84 | TNKS (0.56) | TNKSTNKS2PARP1 | |
| SCHEMBL16432435 | 0.82 | TNKS (0.76) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17251950 | 0.81 | TNKS (0.65) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17251982 | 0.81 | TNKS (0.70) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17240965 | 0.80 | TNKS (0.66) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL16432467 | 0.80 | TNKS (0.68) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17241056 | 0.80 | TNKS (0.70) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17241025 | 0.79 | TNKS (0.81) | TNKSTNKS2PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140295-B1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-09-12 | — | — | EP | claimed |
| US-9809598-B2 | Heterocyclyl-butanamide derivatives | MERCK PATENT GMBH (DE) | 2017-11-07 | — | — | US | claimed |
| US-20170073347-A1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | claimed |
| CN-106458988-B | Heterocycle-butanamide derivatives | 默克专利股份公司 | 2019-12-03 | — | — | CN | disclosed |
| EP-3140295-B1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-09-12 | — | — | EP | disclosed |
| US-9809598-B2 | Heterocyclyl-butanamide derivatives | MERCK PATENT GMBH (DE) | 2017-11-07 | — | — | US | disclosed |
| US-9809598-B2 | Heterocyclyl-butanamide derivatives | MERCK PATENT GMBH (DE) | 2017-11-07 | — | — | US | disclosed |
| US-9809598-B2 | Heterocyclyl-butanamide derivatives | MERCK PATENT GMBH (DE) | 2017-11-07 | — | — | US | disclosed |
| US-20170073347-A1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170073347-A1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170073347-A1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| WO-2015169421-A1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073347-A1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | TNKS, TANK, TBKBP1 | TNKS 1/4885TNKS2 9/4885PARP1 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.