Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.49 |
| ▸ | NNMT | P40261 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1725393 | 1.00 | KMT2A (0.51) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL1726140 | 0.88 | NPC1 (0.54) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL1726142 | 0.88 | NPC1 (0.54) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL196260 | 0.77 | KMT2A (0.51) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL17844984 | 0.76 | KMT2A (0.51) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL8664419 | 0.75 | FDPS (0.58) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL8664417 | 0.75 | FDPS (0.58) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL15130452 | 0.72 | NPC1 (0.48) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL15130451 | 0.72 | NPC1 (0.48) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL3761569 | 0.72 | KMT2A (0.68) | KMT2AMEN1MAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403833-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |