Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | CDC25A | P30304 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28221470 | 0.93 | HSD17B10 (0.59) | HSD17B10CDC25ACDC25BTDP1POLB | |
| SCHEMBL6597584 | 0.91 | HSD17B10 (0.52) | HSD17B10CDC25ACDC25BTDP1POLB | |
| SCHEMBL829773 | 0.91 | KDM4E (0.60) | HSD17B10CDC25ACDC25BTDP1POLB | |
| SCHEMBL10046617 | 0.89 | POLB (0.63) | HSD17B10CDC25ACDC25BTDP1POLB | |
| SCHEMBL11555300 | 0.89 | LCK (0.48) | HSD17B10TDP1POLBL3MBTL1KDM4E | |
| SCHEMBL30342277 | 0.89 | LCK (0.48) | HSD17B10TDP1POLBL3MBTL1KDM4E | |
| SCHEMBL31161441 | 0.83 | MYC (0.48) | HSD17B10CDC25ACDC25BTDP1POLB | |
| SCHEMBL27748287 | 0.83 | KDM4E (0.55) | HSD17B10CDC25ACDC25BTDP1POLB | |
| SCHEMBL6946130 | 0.83 | KDM4E (0.55) | HSD17B10CDC25ACDC25BTDP1POLB | |
| SCHEMBL2422954 | 0.81 | ALDH1A1 (0.49) | HSD17B10TDP1POLBL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101568351-B | Controlled release composition and process | 3M INNOVATIVE PROPERTIES CO | 2012-05-30 | — | — | CN | disclosed |
| EP-2406250-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-01-18 | — | — | EP | disclosed |
| EP-0722936-B1 | FUSED PYRIDAZINE COMPOUND | EISAI CO LTD (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6218392-B1 | FOR THERAPY AND PROPHYLAXIS OF ISCHEMIC HEART DISEASES SUCH AS ANGINA PECTORIS, MYOCARDIAL INFARCT AND CHRONIC AND ACUTE CARDIAC FAILURE, PULMONARY HYPERTENSION, ARTERIOSCLEROSIS AND BRONCHIAL ASTHMA | EISAI CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| US-5849741-A | Fused pyridazine compounds | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0722936-A1 | FUSED PYRIDAZINE COMPOUND | Eisai Co., Ltd. (JP) | 1996-07-24 | — | — | EP | disclosed |