Ifenprodil

Ifenprodil

SCHEMBL1725512

CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1.OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2B Q13224 9/20 0.69
GRIN1 Q05586 7/20 0.69
CYP3A4 P08684 3/20 0.69
MTOR P42345 3/20 0.69
GMNN O75496 3/20 0.69
TSHR P16473 2/20 0.69
NPSR1 Q6W5P4 2/20 0.69
NFKB1 P19838 2/20 0.69
TP53 P04637 1/20 0.69
ALOX15 P16050 1/20 0.69
THPO P40225 1/20 0.69
BLM P54132 1/20 0.69
ADRA1A P35348 8/20 0.67
ADRA2A P08913 5/20 0.67
HTR2A P28223 5/20 0.67
GRIN2D O15399 5/20 0.67
GRIN2A Q12879 5/20 0.67
GRIN2C Q14957 5/20 0.67
HTR2B P41595 4/20 0.67
GRIN3B O60391 4/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10735604 0.85 GRIN2B (0.64) GRIN2BGRIN1CYP3A4MTORGMNN
Eliprodil SCHEMBL6254237 0.83 GMNN (1.00) GRIN2BGRIN1CYP3A4MTORGMNN
SCHEMBL11055006 0.83 GRIN2B (0.80) GRIN2BGRIN1CYP3A4MTORGMNN
Eliprodil SCHEMBL154047 0.83 GMNN (1.00) GRIN2BGRIN1CYP3A4MTORGMNN
Eliprodil SCHEMBL7517402 0.83 GMNN (1.00) GRIN2BGRIN1CYP3A4MTORGMNN
Eliprodil SCHEMBL7525726 0.82 GMNN (0.98) GRIN2BGRIN1CYP3A4MTORGMNN
Eliprodil SCHEMBL7212849 0.82 GMNN (0.98) GRIN2BGRIN1CYP3A4MTORGMNN
Eliprodil SCHEMBL7521721 0.82 GMNN (0.98) GRIN2BGRIN1CYP3A4MTORGMNN
(R,S)-Ifenprodil SCHEMBL12618846 0.82 GRIN2B (1.00) GRIN2BGRIN1CYP3A4MTORGMNN
(R,S)-Ifenprodil SCHEMBL21614195 0.82 GRIN2B (1.00) GRIN2BGRIN1CYP3A4MTORGMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240207284-A1 METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME SOLENO THERAPEUTICS, INC. 2024-06-27 US disclosed
US-20220047605-A1 SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF SOLENO THERAPEUTICS, INC. 2022-02-17 US disclosed
US-20210322434-A1 METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME SOLENO THERAPEUTICS, INC. 2021-10-21 US disclosed
US-11045478-B2 Salts of potassium ATP channel openers and uses thereof ESSENTIALIS, INC. (US) 2021-06-29 US disclosed
US-10874676-B2 Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome Essentials, Inc. (US) 2020-12-29 US disclosed
US-20200237772-A1 PHARMACEUTICAL FORMULATIONS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF SOLENO THERAPEUTICS, INC. 2020-07-30 US disclosed
US-20200222417-A1 SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF SOLENO THERAPEUTICS, INC. 2020-07-16 US disclosed
EP-3217963-B1 METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME ESSENTIALIS INC (US) 2020-05-20 EP disclosed
US-20200147100-A1 METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME SOLENO THERAPEUTICS, INC. 2020-05-14 US disclosed
US-10456408-B2 Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome ESSENTIALIS, INC. (US) 2019-10-29 US disclosed
WO-2006026469-A2 PHARMACEUTICAL FORMULATIONS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF ESSENTIALIS, INC. (US) 2006-03-09 WO disclosed
WO-2004075832-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CHRONIC PAIN USING DHEA AND DERIVATIVES THEREOF LUCAS JOHN M (US) 2004-09-10 WO disclosed
US-20030133951-A1 Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines PFIZER INC. 2003-07-17 US disclosed
EP-1272218-A2 A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ACUTE, CHRONIC PAIN AND/OR NEUROPATHIC PAIN AND MIGRAINES Pfizer Products Inc. (US) 2003-01-08 EP disclosed
US-20010036943-A1 Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines PFIZER PRODUCTS INC. 2001-11-01 US disclosed
WO-2001076576-A2 A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ACUTE, CHRONIC PAIN AND/OR NEUROPATHIC PAIN AND MIGRAINES PFIZER PRODUCTS INC. (US) 2001-10-18 WO disclosed
EP-0939635-A1 IMPROVED INTRAOCULAR IRRIGATING SOLUTION CONTAINING A POLYAMINE ANTAGONIST ALCON LABORATORIES, INC. (US) 1999-09-08 EP disclosed
EP-0854719-A1 USE OF POLYAMINE ANTAGONISTS FOR THE TREATMENT OF GLAUCOMA SYNTHELABO (FR) 1998-07-29 EP disclosed
WO-1998019678-A1 IMPROVED INTRAOCULAR IRRIGATING SOLUTION CONTAINING A POLYAMINE ANTAGONIST ALCON LABORATORIES, INC. (US) 1998-05-14 WO disclosed
WO-1997002823-A1 USE OF POLYAMINE ANTAGONISTS FOR THE TREATMENT OF GLAUCOMA SYNTHELABO (FR) 1997-01-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10874676-B2 Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome KCNJ1, KCNJ11, KCNN1 GRIN2B 1284/4885GRIN1 1313/4885CYP3A4 3202/4885
US-20220047605-A1 SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF KCNJ1, KCNJ11, KCNJ2 GRIN2B 1627/4885GRIN1 1630/4885CYP3A4 333/4885
US-20200222417-A1 SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF KCNJ1, KCNJ11, KCNJ2 GRIN2B 1627/4885GRIN1 1630/4885CYP3A4 333/4885
US-20210322434-A1 METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME KCNJ1, KCNJ11, KCNN1 GRIN2B 1284/4885GRIN1 1313/4885CYP3A4 3202/4885
US-20240207284-A1 METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME KCNJ1, KCNJ11, KCNN1 GRIN2B 1284/4885GRIN1 1313/4885CYP3A4 3202/4885
US-10456408-B2 Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome KCNJ1, KCNJ11, KCNN1 GRIN2B 1284/4885GRIN1 1313/4885CYP3A4 3202/4885
US-20200237772-A1 PHARMACEUTICAL FORMULATIONS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF KCNJ1, KCNJ11, KCNJ8 GRIN2B 2379/4885GRIN1 2346/4885CYP3A4 302/4885
US-20200147100-A1 METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME KCNJ1, KCNJ11, KCNN1 GRIN2B 1284/4885GRIN1 1313/4885CYP3A4 3202/4885
US-11045478-B2 Salts of potassium ATP channel openers and uses thereof KCNJ1, KCNJ11, KCNJ2 GRIN2B 1627/4885GRIN1 1630/4885CYP3A4 333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.